Studies report significant increases in fat-free mass and muscle size following a 10-week course of injectable testosterone replacement therapy (TRT), with controlled nutrition and exercise. The findings highlight marked improvements in body weight, fat-free mass, and muscle size of key muscle groups, as objectively measured by advanced techniques like underwater weighing and magnetic resonance imaging. These benefits are attributed to the elevations in testosterone levels achieved through TRT, suggesting similar outcomes with oral testosterone formulations that achieve comparable hormone elevations. Additional studies have shown that while dieting, men receiving a placebo lost both fat and lean mass, whereas weight loss with testosterone treatment was primarily due to loss of body fat. Furthermore, testosterone therapy has been shown to be an effective approach for sustained weight loss in obese hypogonadal men, regardless of the severity of obesity.Fill in

Fill inHigh-quality evidence shows that compared with placebo, injectable testosterone therapy was associated with a substantial improvement in sexual desire (libido), erectile function (EF), sexual activity, and sexual satisfaction in hypogonadal men. These benefits are linked to increased testosterone levels and similar effects can be anticipated with oral testosterone that achieves comparable hormone levels.

Promising associations have been found between cognition and testosterone supplementation in both eugonadal men and men with low testosterone levels, including those with baseline cognitive dysfunction. Low endogenous levels of testosterone may relate to reduced cognitive ability, and testosterone substitution, including oral forms that achieve similar hormone levels, may improve some cognitive functions. Testosterone replacement therapy in young and middle-aged hypogonadal men over two years improved attention, visual scanning ability, executive function, and psychomotor speed.

Testosterone replacement therapy in hypogonadal men improved their positive mood parameters, such as energy, well-being, and friendliness, and decreased negative mood parameters including anger, nervousness, and irritability. These mood enhancements are associated with increased testosterone levels and similar benefits can be expected from increased testosterone levels from oral testosterone.

Our oral testosterone is designed to be absorbed efficiently, minimizing strain on liver function compared to some other oral formulations. Clinical monitoring of liver markers in patients using this formulation has not shown acute adverse effects on liver function. We also regularly monitor these markers in all patients to ensure continued safety. Additionally, studies on similar oral testosterone formulations suggest the potential to maintain or normalize liver enzyme levels, including in patients with elevated baseline values. While further research is warranted, these findings may indicate potential liver health benefits in specific contexts, such as conditions related to fatty liver. Our formulation utilizes native testosterone, or testosterone base, which is free of esters that modify its half-life. While esterified testosterone products slightly extend the half-life, they are also associated with increased conversion to DHT. In single-dose studies, native testosterone has demonstrated significant increases in serum testosterone levels while keeping DHT levels within normal ranges, providing a balanced approach to hormone optimization.