View All Resources
Article

Early Access to New Products,
e-books & insights

By entering your email you agree to our privacy policy.

Dec 6, 2024

What is Dutasteride?: How it Works, Side Effects and Benefits

Key Takeaways

  • Dutasteride is FDA-approved to treat benign prostatic hyperplasia and also prescribed off-label to treat hair loss in men.
  • Oral and topical dutasteride have both shown effectiveness in reducing hair loss and promoting new hair growth with regular use.
  • You can experience mild side effects while using dutasteride, such as sexual issues like erectile dysfunction, decreased sex drive, or trouble finishing, but these side effects are most often manageable with the right guidance .

Hair loss is a common concern among men as they get older — and with 30 to 50% of men affected by male pattern baldness by age 50, it’s no wonder why.

But there’s good news for those suffering hair loss symptoms…

Dutasteride is one of the most effective hair loss solutions that not only helps you keep the hair you have, but also stimulates the growth of new hair.

In this article you’ll learn everything dutasteride can do as a hair loss medication. Let’s take a closer look at dutasteride benefits, side effects, cost, and everything else you need to know before starting your hair loss treatment.

What is dutasteride?

Dutasteride is a potent dual inhibitor of the 5-alpha reductase enzyme, which plays a key role in converting testosterone into dihydrotestosterone (DHT), a hormone linked to hair loss and other conditions. Dutasteride works by blocking both type I and type II forms of this enzyme, leading to a significant reduction in DHT levels.

This dual inhibition makes dutasteride more effective than other 5-alpha reductase inhibitors in managing conditions associated with excess DHT, such as androgenetic alopecia, or more simply put, balding.

By reducing DHT, dutasteride helps prevent hair follicle miniaturization, promotes hair regrowth, and can alleviate symptoms of conditions like benign prostatic hyperplasia (BPH).

It is widely recognized for its potent effects on DHT suppression and its ability to improve hair density and growth in those suffering from advanced hair loss.

Often taken as an oral tablet in 0.5 mg doses, dutasteride is also available as a topical solution.

Oral dutasteride vs. Topical dutasteride

There’s no clear answer in the debate of oral dutasteride vs. topical dutasteride, Which form of dutasteride treatment you choose will rely on several factors such as hair regrowth goals, results, and personal preference.

Topical dutasteride stimulates effective hair regrowth while minimizing systemic absorption and the risk of side effects associated with oral formulations.

However, oral dutasteride provides systemic hair regrowth beyond just localized areas making it effective for advanced hair loss cases..

Is dutasteride effective?

Yes, research shows that oral and topical dutasteride is one of the most effective medications for treating hair loss.

One study looked at the efficacy of dutasteride compared to a placebo among 17 pairs of identical twins with male pattern baldness. Results showed that the men who used dutasteride experienced significantly improved hair growth and a reduced progression of hair loss.

In another study from 2020, men experienced an increase in the average amount of hair after taking oral dutasteride for at least 24 weeks.

Dutasteride side effects

Possible side effects of dutasteride include:

  • Trouble having or maintaining an erection
  • Trouble ejaculating
  • Lower sex drive

There’s also a risk of more serious side effects, although these are uncommon:

  • Swelling of the face or throat
  • Changes or pain in the breast
  • Difficulty breathing and/or swallowing
  • Peeling skin

There’s also some research suggesting dutasteride may have negative effects on fertility, mainly a decline in sperm count. Though this appears to be reversible after someone stops taking the medication.

While dutasteride side effects can occur, they are often mild. With the right care and knowledge dutasteride side effects are manageable.

Does dutasteride work better when combined with other treatments?

We know that dutasteride works well enough on its own to treat hair loss. But to get even better results, does dutasteride work well when combined with other ingredients?

One study saw a topical solution of dutasteride combined with finasteride and minoxidil — two common hair loss medications — improve hair growth among men with male pattern baldness after 90 days.

Is dutasteride right for you?

Dutasteride is an effective safe option for treating hair loss or benign prostatic hyperplasia.

While side effects are possible, such as sexual dysfunction like trouble finishing or erectile dysfunction they are most often minimal and, with the right guidance, manageable.

The results of dutasteride on hair loss are significant, with several studies showing improvement after consistent use.

But the only way to know if dutasteride is effective for your hair loss goals is to try it and start your hair regrowth journey today.

Disclaimer: The contents of this article, including, but not limited to, text, graphics, images, and other information, is for information purposes only and does not constitute medical advice. The information contained herein is not a substitute for and should never be relied upon for professional medical advice. The content is not meant to be complete or exhaustive or to be applicable to any specific individual's medical condition. You should consult a licensed healthcare professional before starting any health protocol and seek the advice of your physician or other medical professional if you have questions or concerns about a medical condition. Always talk to your doctor about the risks and benefits of any treatment. Never disregard or delay seeking professional medical advice or treatment because of something you have read on this site. Maximus does not recommend, endorse, or make any representation about the efficacy, appropriateness, or suitability of any specific test, products, procedures, treatments, services, opinions, healthcare providers or other information contained herein. Maximus is not responsible for, nor will they bear any liability for, the content provided herein or any actions or outcomes resulting from or related to its use.

References:

  1. Abdallah, M., El-Zawahry, K., & Besar, H. (2009). Mesotherapy using Dutasteride-Containing Solution in Male Pattern Hair Loss: a Controlled Pilot Study. 20(1), 137-145. https://www.thalassa-lisboa.com/storage/app/media/uploaded-files/meso%20dudasteride%20%20egyptiens.pdf
  2. 5-Alpha Reductase Inhibitor Information. (2016, October 14). FDA. https://www.fda.gov/drugs/information-drug-class/5-alpha-reductase-inhibitor-information
  3. Al-Horani RA, Patel P. Dutasteride. [Updated 2024 Mar 20]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. https://www.ncbi.nlm.nih.gov/books/NBK603726/
  4. Amory, J. K., Wang, C., Swerdloff, R. S., Anawalt, B. D., Matsumoto, A. M., Bremner, W. J., Walker, S. E., Haberer, L. J., & Clark, R. V. (2007). The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men. The Journal of Clinical Endocrinology & Metabolism, 92(5), 1659-1665. https://academic.oup.com/jcem/article-abstract/92/5/1659/2598215
  5. Asfour L, Cranwell W, Sinclair R. Male Androgenetic Alopecia. [Updated 2023 Jan 25]. In: Feingold KR, Anawalt B, Blackman MR, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-. https://www.ncbi.nlm.nih.gov/books/NBK278957/
  6. Development & Approval Process | Drugs. (2022, August). U.S. Food & Drug Administration. https://www.fda.gov/drugs/development-approval-process-drugs
  7. Dutasteride. (n.d.). GoodRX. https://www.goodrx.com/dutasteride
  8. Dutasteride. (n.d.). Medline Plus. https://medlineplus.gov/druginfo/meds/a603001.html
  9. Herz-Ruelas, M. E., Álvarez-Villalobos, N. A., Millán-Alanís, J. M., de León-Gutiérrez, H., Ocampo-Garza, S. S., Gómez-Flores, M., & Grimalt, R. (2020). Efficacy of Intralesional and Oral Dutasteride in the Treatment of Androgenetic Alopecia: A Systematic Review. Skin appendage disorders, 6(6), 338–345. https://pmc.ncbi.nlm.nih.gov/articles/PMC7706484/
  10. Kinter KJ, Amraei R, Anekar AA. Biochemistry, Dihydrotestosterone. [Updated 2023 Jul 30]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. https://www.ncbi.nlm.nih.gov/books/NBK557634/
  11. Nada, E., Elmaged, W. A., & Sharkawy, R. E. (2018). Topical dutasteride with microneedling in treatment of male androgenetic alopecia. Sohag Medical Journal, 22(1), 387-400. https://www.researchgate.net/publication/334740272_Topical_dutasteride_with_microneedling_in_treatment_of_male_androgenetic_alopecia
  12. Rabasseda X. (2004). Dutasteride: a potent dual inhibitor of 5-alpha-reductase for benign prostatic hyperplasia. Drugs of today (Barcelona, Spain : 1998), 40(8), 649–661. https://pubmed.ncbi.nlm.nih.gov/15510237/
  13. Rafi, A. W., & Katz, R. M. (2011). Pilot Study of 15 Patients Receiving a New Treatment Regimen for Androgenic Alopecia:  The Effects of Atopy on AGA. International Scholarly Research Notices, 2011(1), 241953. https://onlinelibrary.wiley.com/doi/10.5402/2011/241953
  14. Stough, D. (2007). Dutasteride improves male pattern hair loss in a randomized study in identical twins. Journal of Cosmetic Dermatology, 6(1), 9-13. https://onlinelibrary.wiley.com/doi/10.1111/j.1473-2165.2007.00297.x
View All Resources

Early Access to New Products,
e-books & insights

By entering your email you agree to our privacy policy.