TRT works. At this point, the benefits of TRT are an undeniable fact. It was equally undeniable that starting exogenous testosterone therapy meant sacrificing your fertility—until now. At Maximus, we recognized the need for enhancing testosterone levels while preserving fertility. This realization led us to develop and test the Oral TRT + Enclomiphene Protocol, a groundbreaking approach that delivers the benefits of TRT without the common downsides.
Our clinical study on this protocol has yielded remarkable results, demonstrating that oral testosterone, when combined with enclomiphene citrate, can significantly increase testosterone levels while maintaining key fertility markers. In this article, we’ll explore how our study was conducted, what we discovered, and what this means for the future of TRT.
Understanding the need for a new approach
Before diving into the study, it’s important to understand the challenge we set out to solve.
Male hypogonadism—a condition in which the body produces insufficient testosterone—can stem from two primary causes:
- Primary hypogonadism, caused by testicular dysfunction, typically requires direct testosterone replacement.
- Secondary hypogonadism, resulting from dysfunction in the hypothalamic-pituitary axis can often be treated with medications that stimulate the body's own testosterone production, like enclomiphene.
Traditional TRT, while effective in increasing testosterone, often suppresses natural testosterone production and reduces fertility by inhibiting the body’s release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Many men, especially those who wish to maintain fertility, avoid TRT due to these concerns.
Alternative treatments such as Selective Estrogen Receptor Modulators (SERMs), Aromatase Inhibitors, and human chorionic gonadotropin (hCG) can help stimulate testosterone production while preserving fertility. However, they do not offer the dose-dependent increases in testosterone that exogenous TRT provides.
We wanted to develop a therapy that combines the best of both worlds—allowing men to enjoy the high testosterone levels associated with TRT while avoiding fertility suppression.
This led to our Oral TRT + Enclomiphene Protocol, which combines oral native testosterone with enclomiphene citrate.
How we conducted our study
To evaluate the effectiveness of the Oral TRT + Enclomiphene Protocol, we conducted a rigorous study involving 79 men, including both hypogonadal (low testosterone) and eugonadal (normal testosterone) participants.
Key study objectives
Our study aimed to determine:
- The optimal dosage of oral testosterone for maximum efficacy
- How dietary fat intake affects testosterone absorption
- The best timing for blood tests to measure peak testosterone levels
- The impact of our protocol on fertility markers such as LH and FSH
- The effects on estrogen balance, mental health, energy, and overall well-being
Methodology
Participants were given our oral testosterone formulation along with enclomiphene citrate, a selective estrogen receptor modulator (SERM) known to stimulate natural testosterone production by increasing LH and FSH levels.
We measured key hormonal markers, including:
- Total Testosterone (TT) – The overall level of testosterone in the blood
- Free Testosterone (FT) – The bioavailable testosterone that is not bound to proteins and can actively influence bodily functions
- Luteinizing Hormone (LH) & Follicle-Stimulating Hormone (FSH) – Indicators of fertility and natural testosterone production
- Estradiol (E2) – A key estrogen that can rise with traditional TRT, sometimes leading to unwanted side effects
- Sex Hormone-Binding Globulin (SHBG) – A protein that binds to testosterone, influencing its bioavailability
Participants also completed standardized quality-of-life assessments, including:
- The quantitative Androgen Deficiency in the Aging Male (qADAM) questionnaire, measuring changes in symptoms related to low testosterone
- The Patient Health Questionnaire-4 (PHQ-4), assessing changes in mood, anxiety, and depression
To ensure accurate data collection, we tested participants under different conditions, evaluating the impact of food intake, time of day, and medication timing on testosterone absorption.
Key findings from the study
1. A significant boost in testosterone levels
The Oral TRT + Enclomiphene Protocol led to a 4x increase in total testosterone levels and a 5x increase in free testosterone levels.
These results far matched those of traditional TRT, with the majority of participants achieving testosterone levels above the 99th percentile while maintaining physiological balance.
2. Fertility preservation – a major breakthrough
One of the biggest concerns with TRT is its suppressive effect on fertility. Unlike standard TRT, which reduces LH and FSH to near-zero levels, our protocol successfully preserved these markers within normal ranges.
This means men can benefit from the testosterone-boosting effects of TRT without compromising fertility—a major advancement in hormone optimization therapy.
3. Estrogen regulation – avoiding the common pitfalls of TRT
Many traditional TRT methods lead to an excessive rise in estrogen, often requiring additional medications like aromatase inhibitors to counteract the effects.
Interestingly, our protocol led to a modest reduction in estrogen levels while keeping them within a healthy range. This means fewer side effects like water retention, mood swings, and gynecomastia (excessive breast tissue growth). The proposed theory behind this finding is the increased conversion of testosterone to dihydrotestosterone (DHT), which can act as an aromatase inhibitor.
4. Marked improvements in mood, energy, and quality of life
Over 70% of participants reported increased energy, improved strength and endurance, enhanced work performance, and a better overall quality of life.
Furthermore, 70% of participants reported enhanced libido and erection quality. Most remarkably, the study found an 80% reduction in symptoms of anxiety and depression.
This is a critical finding, as low testosterone is closely linked to mood disorders, fatigue, and decreased motivation. By restoring testosterone levels in a controlled and effective manner, we observed profound improvements in both mental and physical well-being.
Why this matters
For many men, TRT has been an all-or-nothing decision—either accepting potential fertility loss and hormonal imbalances or avoiding treatment altogether.
Our study suggests that oral testosterone combined with enclomiphene offers a middle ground, delivering the benefits of TRT without the usual trade-offs.
By offering a convenient, non-invasive, and fertility-friendly alternative, we believe this protocol can help more men take control of their hormonal health without hesitation.
A new era for testosterone therapy
The Oral TRT+ Enclomiphene Protocol represents a major step forward in men’s health.
By combining oral testosterone with enclomiphene citrate, we have developed a protocol that maximizes testosterone levels, preserves fertility, improves quality of life, and avoids the common pitfalls of traditional TRT.
As research continues, we believe this approach will redefine testosterone therapy, making it more accessible, effective, and sustainable for men looking to optimize their health.
If you’re ready to take control of your testosterone levels without sacrificing fertility or convenience, our protocol may be the solution you’ve been waiting for.
--
Want to read the full white paper? Click here.
