PT-141 is found to be generally safe and well-tolerated. However, like all medications, it may come with some side effects.
According to a study of PT-141 for use in erectile dysfunction, it causes the following side effects at a dose of 10 mg when taken intranasally:
- Nausea (12.8%)
- Flushing (10.5%)
- Diaphoresis / excessive sweating (9.3%)
- Low back pain (7.0%)
- Taste disturbance (4.7%)
- Headache (3.5%)
- Somnolence / drowsiness (1.2%)
It is important to note that these side effects are observed at a dose of 10 mg, which is higher than the dose used in the LOVER Protocol, which uses 2000 mcg. In addition, the route of administration in this study was intranasal, while the LOVER Protocol uses an orally dissolving tablet.
Another study in healthy male subjects found no side effects at 4 mg and only a couple reports of flushing at 7 mg (intranasal administration), but notably sample sizes were small.
The LOVER Protocol by Maximus is intended to boost your sexual health and performance for the long-term. It contains PT-141 2000 mcg and tadalafil 5 mg.
Reference
Safarinejad MR, Hosseini SY. Salvage of sildenafil failures with bremelanotide: a randomized, double-blind, placebo controlled study. J Urol. 2008;179(3):1066-1071. doi:10.1016/j.juro.2007.10.063
Diamond LE, Earle DC, Rosen RC, Willett MS, Molinoff PB. Double-blind, placebo-controlled evaluation of the safety, pharmacokinetic properties and pharmacodynamic effects of intranasal PT-141, a melanocortin receptor agonist, in healthy males and patients with mild-to-moderate erectile dysfunction. Int J Impot Res. 2004 Feb;16(1):51-9. doi: 10.1038/sj.ijir.3901139. PMID: 14963471.
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